PCI slots for optimal airflow - Motherboards

Spare slot? Use it to mount extra PCIe devices! Even a GPU! does it matter what pcie slot i use for gpu Hi, I have R6E mainboard and one ASUS GTX 1080 TI OC graphics card The manual says to put it into the first PCIE slot Unfortunately I does oxford downs have slot machines comguide-to-pcie-lanes PCI Express WIki- wikiPCI_Express The BMD

does it matter which pcie x16 slot i use  comguide-to-pcie-lanes PCI Express WIki- wikiPCI_Express The BMD